Applied Therapeutics: The Clinical Use of Drugs

All the contributors are leading clinicians with many years of evidence-based care. As students progress through the text, they will learn the basics of common diseases and disorders and develop practical problem-solving skills for devising and implementing successful drug treatment regimens.

Color Atlas of Immunology

This is a pocket atlas flexibook. Complex processes are well-illustrated in clear images, that are not burdened with unnecessary details. Following an introductory part and a section on laboratory methods in immunology, the bulk of the book concentrates on the manifestations of immunological diseases in the human body, providing comprehensive capsule descriptions of all common immmune diseases.

CCDC GOLD Suite 4.12 - CADD Molecular Docking software

The GOLD Suite consists of the following packages: Hermes for 3D visualisation pre- and post-docking, interactive docking setup.Hermes is a 3D visualiser with particular emphasis on functionality for the analysis of protein-ligand interactions.GOLD for protein-ligand docking:GOLD is a program for calculating the docking modes of small molecules in protein binding sites and is provided as part of the GOLD Suite, a package of programs for structure visualisation and manipulation (Hermes), for protein-ligand docking (GOLD) and for post-processing (GoldMine) and visualisation of docking results. Hermes acts as a hub for many of CCDCs products, for more information please refer to the Hermes product page.GoldMine for post-processing of docking results:GoldMine is a tool for post-processing of GOLD docking results.
GoldMine can be used to combine and analyse several docking runs, e.g. docking runs carried out against different protein models may be combined within a GoldMine database and analysed for selectivity and specificity.Docking runs carried out using one protein model but scored using different scoring functions may also be combined and evaluated within a GoldMine database. GoldMine is provided as part of the GOLD Suite, a package of programs for structure visualisation and manipulation (Hermes), for protein-ligand docking (GOLD) and for post- processing (GoldMine) and visualisation of docking results.

Spectrometric Identification Of Organic Compounds

This book is characterized by its problem-solving approach with extensive reference charts and tables. First published in 1962, this was the first book on the identification of organic compounds using spectroscopy. Now considered a classic, it can be found on the shelf of every Organic Chemist. The key strength of this text is the extensive set of real-data problems in Chapters 8 and 9. Even professional chemists use these spectra as reference data. Spectrometric Identification of Organic Compounds is written by and for organic chemists, and emphasizes the synergistic effect resulting from the interplay of the spectra.

Molecular Biopharmaceutics

This is an introductory textbook on molecular biopharmaceutics. Molecular biopharmaceutics involves the study of drug absorption, transport and delivery at the molecular level. In particular, increasing knowledge of the molecular structure and function of membrane transporter proteins and the understanding that they play a significant role in drug transport across biological membranes has lead to growing interest in this area from the pharmaceutical industry. This emerging knowledge of membrane transporter proteins has implications for understanding drug disposition and in turn for the development of more effective drug delivery strategies.
The proposed text will provide an overview of the field of molecular biopharmaceutics, and will explain its importance in drug development. It will focus on describing the interplay between the chemistry of drug molecules and membrane transporters, and will guide researchers in setting up experiments that may help in understanding the mechanisms and kinetics involved in drug absorption, transport and delivery.

BRS Microbiology - Immunology

BRS Microbiology and Immunology is a popular volume in the Board Review Series for medical students. Written in a concise, flexible, outline format, this book is intended to cover topics most commonly tested on USMLE. Included are 300 to 500 review questions in the USMLE-style format, and a comprehensive examination. New to the revised Fourth Edition are completely updated content; questions written in vignette format; a page of color plates depicting staining methods; and more information on immunology, parasitology, and fungi.

Pentacle. Advanced Alignment-Independent 3D QSAR - Software

Pentacle is an advanced software tool for obtaining alignment-independent 3D quantitative structure-activity relationships. The program starts from a set of structures, computing highly relevant 3D maps of interaction energies between the molecule and chemical probes (GRID based Molecular Interaction Fields, or MIFs). Pentacle automatically encodes these maps into GRID Independent Descriptors (GRIND and GRIND2 descriptors), which are independent of the alignment of the series, thus bypassing one of the most time-consuming aspects of traditional 3D QSAR.Starting from 3D structures of an active series of compounds, Pentacle is able to build a model within a couple of minutes, and guide the user step-by-step through extracting the most useful information

Key Features :

1. Automatically calculate GRID-based GRIND & GRIND2 descriptors
2. Create and explore models interactively using advanced multivariate analyses, linked to the 3D Molecular Interaction Fields of the series
3. Automatically align structures to aid interpretation using the new CLACC algorithm

Pentacle includes new MIF sampling and encoding algorithms improving on those previously implemented for the Almond GRIND 3D QSAR program. The example shows several TACE inhibitors and the Pentacle 3D QSAR model. One of the important contributions to the activity of the series is a polar interaction (illustrated by the red vectors between the yellow hydrophobic field nodes to the blue hydrogen bond donor field nodes) with Thr347. Pentacle is able to import the compounds, calculate the descriptors, build a model, and help you interpret the model in just couple of minutes.
 

Biopharmaceuticals : Biochemistry and Biotechnology

The latest edition of this highly acclaimed textbook, provides a comprehensive and up-to-date overview of the science and medical applications of biopharmaceutical products. Biopharmaceuticals refers to pharmaceutical substances derived from biological sources, and increasingly, it is synonymous with ‘newer’ pharmaceutical substances derived from genetic engineering or hybridoma technology.

This superbly written review of the important areas of investigation in the field, covers drug production, plus the biochemical and molecular mechanisms of action together with the biotechnology of major biopharmaceutical types on the market or currently under development. There is also additional material reflecting both the technical advances in the area and detailed information on key topics such as the influence of genomics on drug discovery.

Pharmacognosy and Pharmaco-biotechnology__Ashutosh Kar

The legendary success, appreciation, and reliability of the First Edition of Pharmacognosy and Pharmacobiotechnology since 2003 by its august readers has prompted and encouraged the author to bring out the Second Edition, which has undergone a thorough revision, modification, and expansion of the entire text content consisting of Fifteen Chapters. Bearing in mind the latest developments in the field of Pharmacognosy visvis the mode of teaching pattern with specific emphasis upon the ever-increasing advancements accomplished in the field of Phytochemistry as well as Pharmacobiotechnology, the exclusive contents of this compendium has been updated judiciously.